ubiquitin activating enzyme activity

Term ID

GO:0004839

Synonyms

• E1 ubiquitin-activating enzyme

Definition

Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate. Ubiquitin-activating_enzyme

References

• EC:6.2.1.45
• Reactome:R-HSA-8852132
• Reactome:R-HSA-8852133
• Reactome:R-HSA-8852134
• Reactome:R-HSA-8865050
• Reactome:R-HSA-8865090
• Reactome:R-HSA-8865098

Ontology

GO: Molecular Function    QuickGO    AmiGO