Search Ontology:

GO: Molecular Function

prostaglandin-endoperoxide synthase activity

Term ID

GO:0004666

Synonyms

(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase activity
(PG)H synthase activity
fatty acid cyclooxygenase activity
PG synthetase activity
prostaglandin endoperoxide synthetase activity
prostaglandin G/H synthase activity
prostaglandin synthase activity
prostaglandin synthetase activity

Definition

Catalysis of the reaction: (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = A + H2O + prostaglandin H2.

References

EC:1.14.99.1
MetaCyc:PROSTAGLANDIN-ENDOPEROXIDE-SYNTHASE-RXN
RHEA:23728
Reactome:R-HSA-140355
Reactome:R-HSA-2309787

Ontology

GO: Molecular Function QuickGO AmiGO

Relationships

is a type of: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Show first 5 Terms
positively regulated by: positive regulation of prostaglandin-endoperoxide synthase activity

positive regulation of prostaglandin-endoperoxide synthase activity Show first 5 Terms
regulated by: regulation of prostaglandin-endoperoxide synthase activity

regulation of prostaglandin-endoperoxide synthase activity Show first 5 Terms

Phenotype

Phenotype caused by Genes