inositol-3-phosphate synthase activity

Term ID

GO:0004512

Synonyms

• 1L-myo-inositol-1-phosphate lyase (isomerizing)
• D-glucose 6-phosphate cycloaldolase activity
• glucocycloaldolase activity
• glucose 6-phosphate cyclase activity
• glucose-6-phosphate inositol monophosphate cycloaldolase activity
• inositol 1-phosphate synthatase activity
• inositol 1-phosphate synthetase activity

Definition

Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form. 5.5.1.4

References

• EC:5.5.1.4
• KEGG_REACTION:R07324
• MetaCyc:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN
• RHEA:10716
• Reactome:R-HSA-1855178

Ontology

GO: Molecular Function    QuickGO    AmiGO