methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity

Term ID

GO:0004491

Synonyms

• methylmalonate-semialdehyde dehydrogenase (acylating) activity
• MMSA dehydrogenase activity
• MSDH activity

Definition

Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product. (2)

References

• EC:1.2.1.27
• MetaCyc:1.2.1.27-RXN
• Reactome:R-HSA-70893

Ontology

GO: Molecular Function    QuickGO    AmiGO