hydroxymethylglutaryl-CoA synthase activity

Term ID

GO:0004421

Synonyms

• (s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity
• (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)
• 3-hydroxy-3-methylglutaryl CoA synthetase activity
• 3-hydroxy-3-methylglutaryl coenzyme A synthase activity
• 3-hydroxy-3-methylglutaryl coenzyme A synthetase activity
• 3-hydroxy-3-methylglutaryl-CoA synthase activity
• 3-hydroxy-3-methylglutaryl-coenzyme A synthase activity
• acetoacetyl coenzyme A transacetase activity
• acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
• beta-hydroxy-beta-methylglutaryl-CoA synthase activity
• HMG-CoA synthase activity
• hydroxymethylglutaryl coenzyme A synthase activity
• hydroxymethylglutaryl coenzyme A-condensing enzyme
• hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity

Definition

Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H2O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H+.

References

• EC:2.3.3.10
• KEGG_REACTION:R01978
• MetaCyc:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN
• RHEA:10188
• Reactome:R-HSA-191323
• Reactome:R-HSA-73918

Ontology

GO: Molecular Function    QuickGO    AmiGO