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GO: Molecular Function

guanylate cyclase activity

Term ID

GO:0004383

Synonyms

GTP diphosphate-lyase (cyclizing) activity
GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) activity
guanyl cyclase activity
guanylyl cyclase activity
receptor guanylate cyclase activity

Definition

Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate. 4.6.1.2

References

EC:4.6.1.2
MetaCyc:GUANYLCYC-RXN
RHEA:13665
Reactome:R-HSA-392152
Reactome:R-HSA-74885

Ontology

GO: Molecular Function QuickGO AmiGO

Relationships

is part of: cGMP biosynthetic process

cGMP biosynthetic process Show first 5 Terms
is a type of: cyclase activity phosphorus-oxygen lyase activity

cyclase activity phosphorus-oxygen lyase activity Show first 5 Terms
negatively regulated by: guanylate cyclase inhibitor activity negative regulation of guanylate cyclase activity

guanylate cyclase inhibitor activity negative regulation of guanylate cyclase activity Show first 5 Terms
positively regulated by: guanylate cyclase activator activity positive regulation of guanylate cyclase activity

guanylate cyclase activator activity positive regulation of guanylate cyclase activity Show first 5 Terms
regulated by: guanylate cyclase regulator activity regulation of guanylate cyclase activity

guanylate cyclase regulator activity regulation of guanylate cyclase activity Show first 5 Terms

Phenotype

Phenotype caused by Genes