2-isopropylmalate synthase activity

Term ID

GO:0003852

Synonyms

• 3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) activity
• acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
• alpha-IPM synthetase activity
• alpha-isopropylmalate synthase activity
• alpha-isopropylmalate synthetase activity
• alpha-isopropylmalic synthetase activity
• isopropylmalate synthase activity
• isopropylmalate synthetase activity

Definition

Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H+.

References

• EC:2.3.3.13
• KEGG_REACTION:R01213
• MetaCyc:2-ISOPROPYLMALATESYN-RXN
• RHEA:21524

Ontology

GO: Molecular Function    QuickGO    AmiGO