protein-glutamine gamma-glutamyltransferase activity

Term ID

GO:0003810

Synonyms

• factor XIIIa
• fibrin stabilizing factor
• fibrinoligase activity
• glutaminylpeptide gamma-glutamyltransferase activity
• polyamine transglutaminase activity
• protein-glutamine:amine gamma-glutamyltransferase
• R-glutaminyl-peptide:amine gamma-glutamyl transferase activity
• TGase activity
• tissue transglutaminase
• transglutaminase activity

Definition

Catalysis of the reaction: L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4+. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links. 2.3.2.13

References

• EC:2.3.2.13
• MetaCyc:2.3.2.13-RXN
• RESID:AA0124
• RHEA:54816
• Reactome:R-HSA-140851
• Reactome:R-HSA-6810894

Ontology

GO: Molecular Function    QuickGO    AmiGO