Search Ontology:
GO: Molecular Function

protein-glutamine gamma-glutamyltransferase activity

Term ID
GO:0003810
Synonyms
  • factor XIIIa
  • fibrin stabilizing factor
  • fibrinoligase activity
  • glutaminylpeptide gamma-glutamyltransferase activity
  • polyamine transglutaminase activity
  • protein-glutamine:amine gamma-glutamyltransferase
  • R-glutaminyl-peptide:amine gamma-glutamyl transferase activity
  • TGase activity
  • tissue transglutaminase
  • transglutaminase activity
Definition
Catalysis of the reaction: L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4+. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links. 2.3.2.13
References
  • EC:2.3.2.13
  • MetaCyc:2.3.2.13-RXN
  • RESID:AA0124
  • RHEA:54816
  • Reactome:R-HSA-140851
  • Reactome:R-HSA-6810894
Ontology
GO: Molecular Function    QuickGO    AmiGO
Relationships
is a type of
inverse has_part
positively regulated by
regulated by
Phenotype
Phenotype caused by Genes