transcription coregulator activity

Term ID

GO:0003712

Synonyms

• nuclear receptor coreceptor activity
• RNA polymerase II transcriptional cofactor activity
• transcription cofactor activity
• transcription coreceptor activity
• transcriptional co-regulator

Definition

A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. (5)

References

Ontology

GO: Molecular Function    QuickGO    AmiGO