Search Ontology:
GO: Biological Process
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
- Term ID
- GO:0002460
- Synonyms
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- Definition
- An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus. (2)
- References
- Ontology
- GO: Biological Process QuickGO AmiGO
- is a type of
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- has subtype
- negatively regulated by
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- positively regulated by
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- regulated by
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Phenotype
Phenotype caused by Genes