double-strand break repair via homologous recombination

Term ID

GO:0000724

Synonyms

HDR
homologous recombinational repair
homology-directed repair
HRR
Rad51-dependent recombinational repair
Rhp51-dependent recombinational repair

Definition

The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. 10357855

References

Reactome:R-HSA-5693538

Ontology

GO: Biological Process QuickGO AmiGO

Relationships

has parts: DNA synthesis involved in double-strand break repair via homologous recombination

DNA synthesis involved in double-strand break repair via homologous recombination Show first 5 Terms
is a type of: double-strand break repair recombinational repair

double-strand break repair recombinational repair Show first 5 Terms
has subtype: double-strand break repair via break-induced replication double-strand break repair via synthesis-dependent strand annealing double-strand break repair via transcription-associated homologous recombination replication-born double-strand break repair via sister chromatid exchange

double-strand break repair via break-induced replication double-strand break repair via synthesis-dependent strand annealing double-strand break repair via transcription-associated homologous recombination replication-born double-strand break repair via sister chromatid exchange Show first 5 Terms
negatively regulated by: negative regulation of double-strand break repair via homologous recombination

negative regulation of double-strand break repair via homologous recombination Show first 5 Terms
positively regulated by: positive regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair via homologous recombination Show first 5 Terms
regulated by: regulation of double-strand break repair via homologous recombination

regulation of double-strand break repair via homologous recombination Show first 5 Terms

Phenotype

Phenotype caused by Genes