peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity

Term ID

GO:0000224

Synonyms

• glycopeptidase activity
• glycopeptide N-glycosidase activity
• jack-bean glycopeptidase
• N-glycanase activity
• N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase activity
• N-oligosaccharide glycopeptidase activity
• peptide:N-glycanase
• PNGase
• PNGase A
• PNGase F

Definition

Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue. 3.5.1.52

References

• EC:3.5.1.52
• MetaCyc:3.5.1.52-RXN
• Reactome:R-HSA-8850594

Ontology

GO: Molecular Function    QuickGO    AmiGO