SAGA complex

Term ID

GO:0000124

Synonyms

• PCAF complex
• PCAF histone acetylase-associated complex
• Spt-Ada-Gcn5-acetyltransferase complex
• SPT3-TAF9-GCN5 acetylase complex
• SPT3-TAF9-PCAF acetylase complex
• STAGA coactivator complex
• STAGA complex

Definition

A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695). (5)

References

Ontology

GO: Cellular Component    QuickGO    AmiGO