breast large cell neuroendocrine carcinoma

Term ID

DOID:6657

Synonyms

Definition

A breast carcinoma that is characterized by large cell size, polygonal shape, low nuclear-cytoplasmic ratio, finely granular eosinophilic cytoplasm, occasionally prominent nucleoli, peripheral palisading, mitosis, and necrosis and in which greater than 50% of the tumor cells are positive for neuroendocrine markers (NSE, chromogranin A, synaptophysin). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608661/

References

• NCI:C40356
• UMLS_CUI:C1511316

Ontology

Human Disease   ( DOID:6657 )