naive thymus-derived CD4-positive, alpha-beta T cell

Term ID

CL:0000895

Synonyms

naive CD4+ T cell
naive thymus-derived CD4-positive, alpha-beta T lymphocyte
naive thymus-derived CD4-positive, alpha-beta T-cell
naive thymus-derived CD4-positive, alpha-beta T-lymphocyte
T.4Nve.Sp
Th0

Definition

An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive, CD127-positive and CD62L-positive. This cell type develops in the thymus. This cell type is also described as being CD25-negative, CD62L-high, and CD44-low. (3)

References

Ontology

Cell Ontology

Relationships

develops from: mature CD4 single-positive thymocyte

mature CD4 single-positive thymocyte Show first 5 Terms
develops into: activated CD4-positive, alpha-beta T cell

activated CD4-positive, alpha-beta T cell Show first 5 Terms
is a type of: CD4-positive, alpha-beta T cell naive T cell

CD4-positive, alpha-beta T cell naive T cell Show first 5 Terms
has_high_plasma_membrane_amount: L-selectin

L-selectin Show first 5 Terms
has_low_plasma_membrane_amount: CD44 molecule

CD44 molecule Show first 5 Terms
has_plasma_membrane_part: C-C chemokine receptor type 7 interleukin-7 receptor subunit alpha receptor-type tyrosine-protein phosphatase C isoform CD45RA

C-C chemokine receptor type 7 interleukin-7 receptor subunit alpha receptor-type tyrosine-protein phosphatase C isoform CD45RA Show first 5 Terms
lacks_plasma_membrane_part: interleukin-2 receptor subunit alpha

interleukin-2 receptor subunit alpha Show first 5 Terms