osteoclast

Term ID

CL:0000092

Synonyms

chondroclast

Definition

A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive. (4)

References

BTO:0000968
CALOHA:TS-0721
FMA:66781

Ontology

Cell Ontology

Relationships

develops from: monocyte

monocyte Show first 5 Terms
is part of: bone element

bone element Show first 5 Terms
is a type of: bone cell myeloid leukocyte

bone cell myeloid leukocyte Show first 5 Terms
has subtype: mononuclear osteoclast multinuclear osteoclast odontoclast

mononuclear osteoclast multinuclear osteoclast odontoclast Show first 5 Terms
capable_of: bone resorption

bone resorption Show first 5 Terms
has_part: cathepsin K nuclear factor NF-kappa-B p100 subunit proto-oncogene c-Fos tartrate-resistant acid phosphatase type 5 transcription factor PU.1

cathepsin K nuclear factor NF-kappa-B p100 subunit proto-oncogene c-Fos tartrate-resistant acid phosphatase type 5 transcription factor PU.1 Show first 5 Terms
has_plasma_membrane_part: macrophage colony-stimulating factor 1 receptor tumor necrosis factor receptor superfamily member 11A

macrophage colony-stimulating factor 1 receptor tumor necrosis factor receptor superfamily member 11A Show first 5 Terms