Search Ontology:
Cell Ontology
Kupffer cell
- Term ID
- CL:0000091
- Synonyms
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- hepatic macrophage
- littoral cell of hepatic sinusoid
- liver macrophage
- macrophagocytus stellatus
- stellate cell of von Kupffer
- von Kupffer cell
- Definition
- A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system. (4)
- References
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- BTO:0000685
- FMA:14656
- Ontology
- Cell Ontology
- is a type of
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- capable_of
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- has_low_plasma_membrane_amount
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- has_plasma_membrane_part
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- located_in
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