ML228

Term ID

CHEBI:92777

Synonyms

6-phenyl-N-[(4-phenylphenyl)methyl]-3-(2-pyridinyl)-1,2,4-triazin-5-amine
LSM-2978
ML-228
ML228 probe
N-([1,1'-biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine
N-([biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine

Definition

A member of the class of 1,2,4-triazines in which the triazine ring is substituted at positions 3, 5, and 6 by pyridin-2-yl, ([biphenyl]-4-ylmethyl)amin, and methyl groups, respectively. It is an activator of the hypoxia inducible factor (HIF) pathway.

References

LINCS:LSM-2978
PMID:22172704
PMID:26987747
PMID:27383646
PMID:27549025
Reaxys:22196087

Ontology

ChEBI ( EBI )

Relationships

is a type of: 1,2,4-triazines biphenyls pyridines secondary amino compound

1,2,4-triazines biphenyls pyridines secondary amino compound Show first 5 Terms
has_role: hypoxia-inducible factor pathway activator

hypoxia-inducible factor pathway activator Show first 5 Terms

Phenotype

Phenotype resulting from ML228

Phenotype where environments contain ML228

Phenotype modified by environments containing ML228

Human Disease Model