ketotifen

Term ID

CHEBI:92511

Synonyms

10-(1-methyl-4-piperidinylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one
4-(1-methylpiperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one
ketotifen
ketotifene
ketotifeno
ketotifenum

Definition

An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.

References

CAS:34580-13-7
DrugBank:DB00920
Drug_Central:1530
HMDB:HMDB0015056
KEGG:D08105
LINCS:LSM-2637
Patent:DE2111071
Patent:US3682930
Wikipedia:Ketotifen

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: cyclic ketone olefinic compound organic heterotricyclic compound organosulfur heterocyclic compound piperidines ... Show All 6 Terms

cyclic ketone olefinic compound organic heterotricyclic compound organosulfur heterocyclic compound piperidines tertiary amino compound Show first 5 Terms
has_role: anti-asthmatic drug H1-receptor antagonist

anti-asthmatic drug H1-receptor antagonist Show first 5 Terms
inverse is_conjugate_acid_of: ketotifen(1+)

ketotifen(1+) Show first 5 Terms
is_conjugate_base_of: ketotifen(1+)

ketotifen(1+) Show first 5 Terms

Phenotype

Phenotype resulting from ketotifen

Phenotype where environments contain ketotifen

Phenotype modified by environments containing ketotifen

Human Disease Model