Search Ontology:
ChEBI

SU4312

Term ID
CHEBI:92369
Synonyms
  • 3-(4-dimethylamino-benzylidenyl)-2-indolinone
  • 3-[4-(dimethylamino)benzylidene]-1,3-dihydro-2H-indol-2-one
  • 3-[[4-(dimethylamino)phenyl]methylidene]-1H-indol-2-one
  • DMBI
  • SU 4312
  • SU-4312
Definition
A member of the class of oxindoles that is 3-methyleneoxindole in which one of the hydrogens of the methylene group has been replaced by a p-(dimethylamino)phenyl group. SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity.
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from SU4312
Phenotype where environments contain SU4312
Phenotype modified by environments containing SU4312
Human Disease / Model Data
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.