HMN-214

Term ID

CHEBI:91440

Synonyms

• (E)-4-[2-[2-(N-acetyl-N-[4-methoxybenzenesulfonyl]amino)stilbazole]]1-oxide
• (E)-4-[2-[2-[N-acetyl-N-[(p-methoxyphenyl)sulfonyl]amino]phenyl]ethenyl]pyridine 1-oxide
• HMN 214
• HMN214
• IVX 214
• IVX-214
• IVX214
• N-[(4-methoxyphenyl)sulfonyl]-N-[2-[(1E)-2-(1-oxido-4-pyridinyl)ethenyl]phenyl]acetamide
• N-[(4-methoxyphenyl)sulfonyl]-N-{2-[(E)-2-(1-oxidopyridin-4-yl)ethenyl]phenyl}acetamide

Definition

An N-sulfonylcarboxamide that is N-[(4-methoxyphenyl)sulfonyl]acetamide in which the hydrogen of the NH group is substituted by a 2-[(E)-2-(1-oxidopyridin-4-yl)ethenyl]phenyl group. It is a potent inhibitor of polo-like kinase 1 (PLK1) that exhibits antineoplastic activity.

References

• CAS:173529-46-9
• LINCS:LSM-1192
• PMID:14583495
• PMID:14586206
• PMID:15605126
• PMID:16951237
• PMID:19474163
• PMID:25681050
• PMID:35631350
• PMID:36830618

Ontology

ChEBI  ( EBI )