Search Ontology:
ChEBI
GW843682X
- Term ID
- CHEBI:91334
- Synonyms
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- 5-(5,6-dimethoxy-1-benzimidazolyl)-3-[[2-(trifluoromethyl)phenyl]methoxy]-2-thiophenecarboxamide
- 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)benzyl]oxy}thiophene-2-carboxamide
- 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)phenyl]methoxy}thiophene-2-carboxamide
- GW 843682X
- GW-843682X
- GW843682
- Definition
- A member of the class of benzimidazoles that is 1H-benzimidazole substituted by 5-carbamoyl-4-{[2-(trifluoromethyl)phenyl]methoxy}thiophen-2-yl, methoxy, and methoxy groups at positions 1, 5, and 6, respectively. It is a potent inhibitor of PLK1 and PLK3 (IC50 = 2.2 and 9.1 nM respectively).
- References
-
- CAS:660868-91-7
- LINCS:LSM-1014
- PMID:17267659
- PMID:18616938
- PMID:19421227
- PMID:21436619
- PMID:21474997
- PMID:21637161
- PMID:23792639
- PMID:24205328
- PMID:26055176
- PMID:27198987
- PMID:36591293
- PMID:37181811
- PMID:38614382
- Ontology
- ChEBI ( EBI )
- is a type of
-
- has_role
-
Phenotype
Phenotype resulting from GW843682X
Phenotype where environments contain GW843682X
Phenotype modified by environments containing GW843682X
Human Disease Model