Search Ontology:
ChEBI
BMS-453
- Term ID
- CHEBI:90739
- Synonyms
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- 4-[(E)-2-(5,5-dimethyl-8-phenyl-5,6-dihydronaphthalen-2-yl)vinyl]benzoic acid
- BMS 189453
- BMS 453
- BMS-189453
- BMS189453
- BMS453
- Definition
- A member of the class of dihydronaphthalenes that is 1,2-dihydronaphthalene which is substituted at positions 1, 1, 4, and 6 by methyl, methyl, phenyl, and 2-(p-carboxyphenyl)vinyl groups, respectively (the E isomer). It is a potent retinoic acid receptor gamma (RARbeta) agonist that acts as an antagonist against RARalpha and RARgamma.
- References
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- CAS:166977-43-1
- PMID:12563696
- PMID:21107276
- PMID:22423954
- PMID:24720764
- PMID:26469117
- PMID:27261179
- Reaxys:24186643
- Ontology
- ChEBI ( EBI )
- is a type of
-
- has_role
-
Phenotype
Phenotype resulting from BMS-453
Phenotype where environments contain BMS-453
Phenotype modified by environments containing BMS-453
Human Disease / Model Data