Search Ontology:
ChEBI
sotrastaurin
- Term ID
- CHEBI:90531
- Synonyms
-
- 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]-1H-pyrrole-2,5-dione
- AEB 071
- AEB-071
- AEB071
- sotrastaurin
- sotrastaurina
- sotrastaurine
- sotrastaurinum
- Definition
- A member of the class of maleimides that is maleimide which is substituted at position 3 by an indol-3-yl group and at position 4 by a quinazolin-4-yl group, which in turn is substituted at position 2 by a 4-methylpiperazin-1-yl group. It is a potent and selective inhibitor of protein kinase C and has been investigated as an immunosuppresant in renal transplant patients.
- References
-
- CAS:425637-18-9
- KEGG:D09671
- LINCS:LSM-42761
- PDBeChem:LW4
- PMID:19491325
- PMID:19827831
- PMID:20003043
- PMID:20683390
- PMID:21142580
- PMID:21157403
- PMID:21324920
- PMID:21564523
- PMID:21883905
- PMID:25634538
- PMID:25677074
- Reaxys:13012870
- Ontology
- ChEBI ( EBI )
- is a type of
-
- has_role
-
Phenotype
Phenotype resulting from sotrastaurin
Phenotype where environments contain sotrastaurin
Phenotype modified by environments containing sotrastaurin
Human Disease / Model Data