Search Ontology:
ChEBI
quinapril
- Term ID
- CHEBI:8713
- Synonyms
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- (3S)-2-{(2S)-2-[(1S)-1-ethoxycarbonyl-3-phenylpropylamino]propanoyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
- (3S)-2-{N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
- (3S)-2-{N-[(2S)-1-ethoxycarbonyl-4-phenylbutan-2-yl]-L-alanyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
- quinapril
- quinaprilum
- Definition
- A member of the class of isoquinolines that is (3S)-2-L-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid in which the alpha-amino group of the alanyl residue has been substituted by a 1-ethoxycarbonyl-4-phenylbutan-2-yl group (the all-S isomer). A prodrug for quinaprilat (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) used (generally as the hydrochloride salt) for the treatment of hypertension and congestive heart failure.
- References
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- CAS:85441-61-8
- DrugBank:DB00881
- Drug_Central:2340
- KEGG:C07398
- KEGG:D03752
- LINCS:LSM-3620
- PMID:17404826
- PMID:27165572
- PMID:27169890
- PMID:29980144
- Patent:US4344949
- Wikipedia:Quinapril
- Ontology
- ChEBI ( EBI )
- is a type of
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- has_role
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Phenotype
Phenotype resulting from quinapril
Phenotype where environments contain quinapril
Phenotype modified by environments containing quinapril
Human Disease / Model Data