Search Ontology:
ChEBI

Src Inhibitor-1

Term ID
CHEBI:78332
Synonyms
  • (4'-oxyphenyl-phenylamino)-6,7-dimethoxyquinazoline
  • 4-(4'-phenoxyanilino)-6,7-dimethoxyquinazoline
  • 6,7-dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine
  • 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine
  • SKI-1
  • Src kinase inhibitor I
  • Src-l1
Definition
A member of the class of quinazolines that is quinazoline which is substituted at position 4 by a p-phenoxyanilino group and at positions 6 and 7 by methoxy groups. It is a potent, competitive dual site (both the ATP- and peptide-binding) Src kinase inhibitor. Src Inhibitor-1 is one of the 'gold standards' for Src kinase inhibition that has been shown to use PP1 or PP2 in parallel with Src-I1 to inhbit Src family kinases.
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from Src Inhibitor-1
Phenotype where environments contain Src Inhibitor-1
Phenotype modified by environments containing Src Inhibitor-1
Human Disease Model
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