Search Ontology:
ChEBI

dexverapamil hydrochloride

Term ID
CHEBI:77739
Synonyms
  • (2R)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-isopropylpentanenitrile hydrochloride
  • (4R)-4-cyano-4-(3,4-dimethoxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-N,5-dimethylhexan-1-aminium chloride
  • dexverapamil HCl
  • dexverapamil.HCl
Definition
A hydrochloride salt resulting from the reaction of equimolar amounts of dexverapamil and hydrogen chloride. It competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1, EC 3.6.3.44), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. Dexverapamil hydrochloride exhibits lower calcium antagonistic activity and toxicity than racemic verapamil hydrochloride.
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_part
has_role
inverse has_part
inverse is_enantiomer_of
is_enantiomer_of
Phenotype
Phenotype resulting from dexverapamil hydrochloride
Phenotype where environments contain dexverapamil hydrochloride
Phenotype modified by environments containing dexverapamil hydrochloride
Human Disease Model