Search Ontology:
ChEBI
dexverapamil hydrochloride
- Term ID
- CHEBI:77739
- Synonyms
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- (2R)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-isopropylpentanenitrile hydrochloride
- (4R)-4-cyano-4-(3,4-dimethoxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-N,5-dimethylhexan-1-aminium chloride
- dexverapamil HCl
- dexverapamil.HCl
- Definition
- A hydrochloride salt resulting from the reaction of equimolar amounts of dexverapamil and hydrogen chloride. It competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1, EC 3.6.3.44), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. Dexverapamil hydrochloride exhibits lower calcium antagonistic activity and toxicity than racemic verapamil hydrochloride.
- References
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- PMID:21544450
- Reaxys:6710895
- Ontology
- ChEBI ( EBI )
- is a type of
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- has_part
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- has_role
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- inverse has_part
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- inverse is_enantiomer_of
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- is_enantiomer_of
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Phenotype
Phenotype resulting from dexverapamil hydrochloride
Phenotype where environments contain dexverapamil hydrochloride
Phenotype modified by environments containing dexverapamil hydrochloride
Human Disease Model