dexverapamil hydrochloride

Term ID

CHEBI:77739

Synonyms

(2R)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-isopropylpentanenitrile hydrochloride
(4R)-4-cyano-4-(3,4-dimethoxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-N,5-dimethylhexan-1-aminium chloride
dexverapamil HCl
dexverapamil.HCl

Definition

A hydrochloride salt resulting from the reaction of equimolar amounts of dexverapamil and hydrogen chloride. It competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1, EC 3.6.3.44), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. Dexverapamil hydrochloride exhibits lower calcium antagonistic activity and toxicity than racemic verapamil hydrochloride.

References

PMID:21544450
Reaxys:6710895

Ontology

ChEBI ( EBI )

Relationships

is a type of: hydrochloride

hydrochloride Show first 5 Terms
has_part: dexverapamil(1+)

dexverapamil(1+) Show first 5 Terms
has_role: EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor

EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor Show first 5 Terms
inverse has_part: verapamil hydrochloride

verapamil hydrochloride Show first 5 Terms
inverse is_enantiomer_of: (S)-verapamil hydrochloride

(S)-verapamil hydrochloride Show first 5 Terms
is_enantiomer_of: (S)-verapamil hydrochloride

(S)-verapamil hydrochloride Show first 5 Terms

Phenotype

Phenotype resulting from dexverapamil hydrochloride

Phenotype where environments contain dexverapamil hydrochloride

Phenotype modified by environments containing dexverapamil hydrochloride

Human Disease / Model Data