oxyphenbutazone

Term ID

CHEBI:76258

Synonyms

• 1-(p-Hydroxyphenyl)-2-phenyl-4-butyl-3,5-pyrazolidinedione
• 1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-butylpyrazolidine
• 1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-n-butylpyrazolidine
• 3,5-Dioxo-1-phenyl-2-(p-hydroxyphenyl)-4-N-butylpyrazolidene
• 4-Butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione
• 4-Butyl-1-(p-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione
• 4-Butyl-2-(4-hydroxyphenyl)-1-phenyl-3,5-dioxopyrazolidine
• 4-Butyl-2-(p-hydroxyphenyl)-1-phenyl-3,5-pyrazolidinedione
• Hydroxyphenylbutazon
• Oxi-fenibutol
• oxifenbutazona
• Oxifenylbutazon
• Oxiphenbutazonum
• oxyphenbutazone
• oxyphenbutazonum
• Oxyphenylbutazone
• p-Hydroxyphenylbutazone
• p-Oxyphenylbutazone

Definition

A metabolite of phenylbutazone obtained by hydroxylation at position 4 of one of the phenyl rings. Commonly used (as its hydrate) to treat pain, swelling and stiffness associated with arthritis and gout, it was withdrawn from the market 1984 following association with blood dyscrasis and Stevens-Johnson syndrome.

References

• CAS:129-20-4
• DrugBank:DB03585
• Drug_Central:2036
• KEGG:C19494
• KEGG:D08324
• LINCS:LSM-5029
• PMID:1222682
• PMID:141661
• PMID:14345781
• PMID:18963985
• PMID:19161668
• PMID:20299217
• PMID:21428758
• PMID:23012453
• PMID:23983013
• PMID:2862290
• PMID:380595
• PMID:501546
• PMID:546857
• PMID:6617711
• PMID:6860567
• PMID:6894379
• PMID:7001487
• PMID:7309664
• PMID:7368966
• PMID:766157
• PMID:835859
• Patent:EP642336
• Patent:US2008014272
• Patent:WO2005107748
• Reaxys:307474
• Wikipedia:Oxyphenbutazone

Ontology

ChEBI  ( EBI )

Resources

CTD