(S)-ketorolac

Term ID

CHEBI:76228

Synonyms

(-)-ketorolac
(1S)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
(S)-(-)-ketorolac

Definition

A 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid that has S configuration. While (S)-ketorolac is a COX1 and COX2 inhibitor, both enantiomers exhibit analgesic effects. Racemic ketorolac, known simply as ketorolac, is used (mainly as the tromethamine salt) as a potent analgesic for the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid

5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid Show first 5 Terms
has_role: analgesic cyclooxygenase 1 inhibitor cyclooxygenase 2 inhibitor non-steroidal anti-inflammatory drug

analgesic cyclooxygenase 1 inhibitor cyclooxygenase 2 inhibitor non-steroidal anti-inflammatory drug Show first 5 Terms
inverse has_part: ketorolac

ketorolac Show first 5 Terms
inverse is_enantiomer_of: (R)-ketorolac

(R)-ketorolac Show first 5 Terms
is_enantiomer_of: (R)-ketorolac

(R)-ketorolac Show first 5 Terms

Phenotype

Phenotype resulting from (S)-ketorolac

Phenotype where environments contain (S)-ketorolac

Phenotype modified by environments containing (S)-ketorolac

Human Disease Model