6-aminonicotinamide

Term ID

CHEBI:74514

Synonyms

2-amino-5-carbamoylpyridine
6-amino-3-pyridinecarboxamide
6-aminonicotinamide
6-aminonicotinic acid amide
6-Aminonikotinsaeureamid
6-AN
6-ANA
SR 4388

Definition

A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 6-aminonicotinic acid with ammonia. An inhibitor of the NADP(+)-dependent enzyme, 6-phosphogluconate dehydrogenase, it interferes with glycolysis, resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, such as cisplatin, in killing cancer cells.

References

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: aminopyridine monocarboxylic acid amide primary amino compound

aminopyridine monocarboxylic acid amide primary amino compound Show first 5 Terms
has_functional_parent: 6-aminonicotinic acid

6-aminonicotinic acid Show first 5 Terms
has_role: antimetabolite EC 1.1.1.44 (NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase) inhibitor teratogenic agent

antimetabolite EC 1.1.1.44 (NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase) inhibitor teratogenic agent Show first 5 Terms

Phenotype

Phenotype resulting from 6-aminonicotinamide

Phenotype where environments contain 6-aminonicotinamide

Phenotype modified by environments containing 6-aminonicotinamide

Human Disease / Model Data