Search Ontology:
ChEBI
temozolomide
- Term ID
- CHEBI:72564
- Synonyms
-
- 3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide
- 3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide
- 3-methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide
- 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
- 8-carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one
- BRN 5547136
- CCRG 81045
- CCRG-81045
- CCRIS 8996
- M & B 39831
- M&B 39831
- MB 39831
- methazolastone
- NSC 362856
- Sch 52365
- Temodal
- Temodar
- temozolomida
- temozolomide
- temozolomidum
- TMZ
- Definition
- An imidazotetrazine that is 3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine which is substituted at positions 3, 4, and 8 by methyl, oxo, and carboxamide groups, respectively. A prodrug for MTIC (5-(3-methyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide, formed by spontaneous hydrolysis of temozolomide in the body), it is used as an oral alkylating agent for the treatment of newly diagnosed malignant glioblastoma multiforme (concomitantly with radiotherapy) and malignant melanoma.
- References
-
- CAS:85622-93-1
- DrugBank:DB00853
- Drug_Central:2589
- HMDB:HMDB0014991
- KEGG:D06067
- LINCS:LSM-4590
- PMID:22680781
- PMID:22818211
- PMID:23246370
- PMID:23254891
- PMID:23293540
- PMID:23335050
- PMID:23362460
- PMID:23377829
- PMID:23385995
- PMID:23389760
- Patent:DE3231255
- Reaxys:5547136
- Wikipedia:Temozolomide
- Ontology
- ChEBI ( EBI )
- Resources
- CTD
- is a type of
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- has_role
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Phenotype
Phenotype resulting from temozolomide
Phenotype where environments contain temozolomide
Phenotype modified by environments containing temozolomide
Human Disease Model