retaspimycin

Term ID

CHEBI:71975

Synonyms

(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(allylamino)-13,20,22-trihydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(22),4,6,10,18,20-hexaen-9-yl carbamate
retaspimycin

Definition

An ansamycin that is tanespimycin in which the benzoquinone moiety has been reduced to the corresponding hydroquinone. A semi-synthetic analogue of geldanamycin, it is used (generally as the hydrochloride salt) in cancer treatment.

References

CAS:857402-23-4
KEGG:D09375
Patent:US2006205705
Patent:US2008255080
Patent:WO2005063714
Patent:WO2005095347
Patent:WO2007002093
Patent:WO2010135426
Reaxys:11329862

Ontology

ChEBI ( EBI )

Relationships

is a type of: ansamycin carbamate ester hydroquinones organic heterobicyclic compound secondary amino compound ... Show All 6 Terms

ansamycin carbamate ester hydroquinones organic heterobicyclic compound secondary amino compound semisynthetic derivative Show first 5 Terms
has_functional_parent: geldanamycin

geldanamycin Show first 5 Terms
has_role: antineoplastic agent Hsp90 inhibitor

antineoplastic agent Hsp90 inhibitor Show first 5 Terms
inverse is_conjugate_acid_of: retaspimycin(1+)

retaspimycin(1+) Show first 5 Terms
is_conjugate_base_of: retaspimycin(1+)

retaspimycin(1+) Show first 5 Terms

Phenotype

Phenotype resulting from retaspimycin

Phenotype where environments contain retaspimycin

Phenotype modified by environments containing retaspimycin

Human Disease / Model Data