BGT226 free base

Term ID

CHEBI:71967

Synonyms

8-(6-methoxypyridin-3-yl)-3-methyl-1-[4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl]-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one

Definition

An imidazoquinoline that is 3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinoline substituted at position 1 by a 3-trifluoromethyl-4-(piperazin-1-yl)phenyl group and at position 8 by a 6-methoxypyridin-3-yl group. A dual PI3K/mTOR inhibitor.

References

LINCS:LSM-6710
Patent:WO2006122806
Reaxys:12748765

Ontology

ChEBI ( EBI )

Relationships

is a type of: aromatic ether imidazoquinoline N-arylpiperazine organofluorine compound pyridines

aromatic ether imidazoquinoline N-arylpiperazine organofluorine compound pyridines Show first 5 Terms
has_role: antineoplastic agent EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor mTOR inhibitor

antineoplastic agent EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor mTOR inhibitor Show first 5 Terms
inverse is_conjugate_acid_of: BGT226(1+)

BGT226(1+) Show first 5 Terms
is_conjugate_base_of: BGT226(1+)

BGT226(1+) Show first 5 Terms

Phenotype

Phenotype resulting from BGT226 free base

Phenotype where environments contain BGT226 free base

Phenotype modified by environments containing BGT226 free base

Human Disease / Model Data