6-hydroxymanzamine A

Term ID

CHEBI:66668

Synonyms

(4aR,7S,7aR,13Z,14aR,15aR,18Z)-5-(6-hydroxy-9H-beta-carbolin-1-yl)-4,4a,9,10,11,12,14a,15-octahydro-3H-7,2-oct[3]enoazocino[1',2':1,5]pyrrolo[2,3-i]isoquinolin-7(1H,7aH)-ol

Definition

An alkaloid that is manzamine A with a hydroxy substituent at position 6. Isolated from Haliclona and Acanthostrongylophora, it exhibits inhibitory activity against Glycogen Synthase Kinase-3 (EC 2.7.11.26).

References

PMID:17708655
PMID:7714542
Reaxys:7240529

Ontology

ChEBI ( EBI )

Relationships

is a type of: alkaloid beta-carbolines isoquinolines

alkaloid beta-carbolines isoquinolines Show first 5 Terms
has_functional_parent: manzamine A

manzamine A Show first 5 Terms
has_role: EC 2.7.11.26 (tau-protein kinase) inhibitor metabolite

EC 2.7.11.26 (tau-protein kinase) inhibitor metabolite Show first 5 Terms

Phenotype

Phenotype resulting from 6-hydroxymanzamine A

Phenotype where environments contain 6-hydroxymanzamine A

Phenotype modified by environments containing 6-hydroxymanzamine A

Human Disease Model