dysidine

Term ID

CHEBI:65816

Synonyms

2-[(4-hydroxy-3,6-dioxo-5-{[(1R,2R,4aS,8aS)-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-2-yl]methyl}cyclohexa-1,4-dien-1-yl)amino]ethanesulfonic acid

Definition

A sesquiterpenoid isolated from the sponge Dysidea sp. that is 5-amino-2-hydroxy-3-methyl-1,4-benzoquinone in which one of the hydrogens of the methyl group is replaced by a 1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-2-yl group and one of the hydrogens attached to the nitrogen is replaced by a 2-sulfoethyl group. Dysidine selectively inhibits human synovial phospholipase A2 (EC 3.1.1.4) with an IC50 = 2.0 muM.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: monohydroxy-1,4-benzoquinones octahydronaphthalenes organosulfonic acid secondary amino compound sesquiterpenoid

monohydroxy-1,4-benzoquinones octahydronaphthalenes organosulfonic acid secondary amino compound sesquiterpenoid Show first 5 Terms
has_role: EC 3.1.1.4 (phospholipase A2) inhibitor metabolite

EC 3.1.1.4 (phospholipase A2) inhibitor metabolite Show first 5 Terms

Phenotype

Phenotype resulting from dysidine

Phenotype where environments contain dysidine

Phenotype modified by environments containing dysidine

Human Disease / Model Data