colossolactone VIII

Term ID

CHEBI:65651

Synonyms

(1R,3R,3aR,11aR,13bR)-3-{(1S)-1-[(2S,3R)-3-hydroxy-5-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]ethyl}-3a,11,11,13b-tetramethyl-9-oxo-1,2,3,3a,4,5,9,11,11a,12,13,13b-dodecahydroindeno[5',4':4,5]cyclohepta[1,2-c]oxepin-1-yl acetate
(22S, 23R)-A,B-dihomo-19-nor-15-beta-acetoxy-23-hydroxy-4-oxa-3-oxolanosta-1,8,19,24-tetraen-26,22-olide

Definition

A tetracyclic triterpenoid that is A,B-dihomo-19-nor-4-oxalanosta-1,8,19,24-tetraen-26,22-olide substituted by an acetoxy group at position 15, a hydroxy group at position 23 and an oxo group at position 3 (the 22S, 23R stereoisomer). It is isolated from the fruiting bodies of the Vietnamese mushroom Ganoderma colossum and displays inhibitory activity towards the enzyme HIV protease.

References

PMID:18547117
Reaxys:18836345

Ontology

ChEBI ( EBI )

Relationships

is a type of: acetate ester delta-lactone epsilon-lactone secondary alcohol tetracyclic triterpenoid

acetate ester delta-lactone epsilon-lactone secondary alcohol tetracyclic triterpenoid Show first 5 Terms
has_parent_hydride: lanostane

lanostane Show first 5 Terms
has_role: HIV protease inhibitor metabolite

HIV protease inhibitor metabolite Show first 5 Terms

Phenotype

Phenotype resulting from colossolactone VIII

Phenotype where environments contain colossolactone VIII

Phenotype modified by environments containing colossolactone VIII

Human Disease Model