colossolactone VII

Term ID

CHEBI:65650

Synonyms

(22S)-3,4-seco-19-acetoxy-4-hydroxylanosta-8,24-dien-26,22-olide 3-methyl ester
methyl 3-[(3aR,6R,7R,9bR)-6-[(acetyloxy)methyl]-7-(2-hydroxypropan-2-yl)-3a,9b-dimethyl-3-{(1S)-1-[(2R)-5-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]ethyl}-2,3,3a,4,5,6,7,8,9,9b-decahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoate

Definition

A tricyclic triterpenoid that is 3,4-seco-lanosta-8,24-diene-26,22-olide 3-methylester substituted by an acetoxy group at position 19 and a hydroxy group at position 4. It is isolated from the fruiting bodies of the Vietnamese mushroom Ganoderma colossum and displays inhibitory activity towards the enzyme HIV protease.

References

PMID:18547117
Reaxys:18836348

Ontology

ChEBI ( EBI )

Relationships

is a type of: acetate ester delta-lactone methyl ester tertiary alcohol tricyclic triterpenoid

acetate ester delta-lactone methyl ester tertiary alcohol tricyclic triterpenoid Show first 5 Terms
has_role: fungal metabolite HIV protease inhibitor

fungal metabolite HIV protease inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from colossolactone VII

Phenotype where environments contain colossolactone VII

Phenotype modified by environments containing colossolactone VII

Human Disease Model