arenamide A

Term ID

CHEBI:65433

Synonyms

(3S,6S,9S,12S,19S)-3-benzyl-6-methyl-9-(2-methylpropyl)-19-[(2S)-octan-2-yl]-12-(propan-2-yl)-1-oxa-4,7,10,13,16-pentaazacyclononadecane-2,5,8,11,14,17-hexone

Definition

A 19-membered cyclodepsipeptide consisting of a 3-hydroxy-4-methyldecanoyl moiety linked to the peptide sequence of 5 amino acids. Isolated from the fermentation broth of marine actinomycete Salinispora arenicola, it has been found to block tumour necrosis factor (TNF)-induced activation of NFkappaB-Luc human embryonic kidney cells.

References

PMID:19117399
Reaxys:19756158

Ontology

ChEBI ( EBI )

Relationships

is a type of: cyclodepsipeptide macrocycle

cyclodepsipeptide macrocycle Show first 5 Terms
has_functional_parent: (3S,4S)-3-hydroxy-4-methyldecanoic acid

(3S,4S)-3-hydroxy-4-methyldecanoic acid Show first 5 Terms
has_role: antineoplastic agent metabolite

antineoplastic agent metabolite Show first 5 Terms

Phenotype

Phenotype resulting from arenamide A

Phenotype where environments contain arenamide A

Phenotype modified by environments containing arenamide A

Human Disease Model