Search Ontology:
ChEBI
fosaprepitant dimeglumine
- Term ID
- CHEBI:64311
- Synonyms
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- (3-{[(2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl]methyl}-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid--1-deoxy-1-(methylamino)-D-glucitol (1/2)
- bis[1-deoxy-1-(methylazaniumyl)-D-glucitol] (3-{[(2R,3S)-2-{(1R,)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl]methyl}-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonate
- Fosaprepitant meglumine
- MK-0517
- Definition
- An organoammonium salt obtained by reaction of fosaprepitant with two equivalents of 1-deoxy-1-(methylamino)-D-glucitol. A substance P/neurokinin 1 (NK1) receptor antagonist. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. Aprepitant has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors, the targets of existing therapies for chemotherapy-induced nausea and vomiting and postoperative nausea and vomiting
- References
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- CAS:265121-04-8
- KEGG:D06597
- PMID:16524680
- PMID:19040346
- PMID:20533894
- PMID:20795794
- Patent:EP2303901
- Patent:US2011130366
- Patent:WO2010018595
- Reaxys:8608007
- Ontology
- ChEBI ( EBI )
- is a type of
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- has_part
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- has_role
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Show first 5 Terms
Phenotype
Phenotype resulting from fosaprepitant dimeglumine
Phenotype where environments contain fosaprepitant dimeglumine
Phenotype modified by environments containing fosaprepitant dimeglumine
Human Disease Model