ritanserin

Term ID

CHEBI:64195

Synonyms

• 6-(2-(4-(bis(p-fluorophenyl)methylene)-piperidino)ethyl)-7-methyl-5H-thiazolo-(3,2-a)pyrimidin-5-one
• 6-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one
• R 55,667
• R-55667
• ritanserin
• ritanserina
• ritanserine
• ritanserinum

Definition

A thiazolopyrimidine that is 5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one which is substituted at position 7 by a methyl group and at position 6 by a 2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl group. A potent and long-acting seratonin (5-hydroxytryptamine, 5-HT) antagonist of the subtype 5-HT2 (Ki = 0.39 nM), it is used in the treatment of a variety of disorders including anxiety, depression and schizophrenia. It has little sedative action.

References

• CAS:87051-43-2
• KEGG:D05738
• LINCS:LSM-2906
• PMID:11897543
• PMID:12905101
• PMID:18801405
• PMID:20825390
• PMID:8974378
• Patent:US4533665
• Reaxys:4913835
• Wikipedia:Ritanserin

Ontology

ChEBI  ( EBI )

Resources

CTD