Search Ontology:
ChEBI

benserazide

Term ID
CHEBI:64187
Synonyms
  • 2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide
  • benserazida
  • benserazide
  • benserazidum
  • DL-serine 2-(2,3,4-trihydroxybenzyl)hydrazide
  • DL-serine 2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide
  • Ro 4-4602
  • Ro 44602
Definition
A carbohydrazide that results from the formal condensation of the carboxy group of DL-serine with the primary amino group of 4-(hydrazinylmethyl)benzene-1,2,3-triol. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as its hydrochloride salt as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide has no antiparkinson actions when given alone.
References
Ontology
ChEBI  ( EBI )
Resources
CTD
Relationships
is a type of
has_role
inverse is_conjugate_acid_of
is_conjugate_base_of
Phenotype
Phenotype resulting from benserazide
Phenotype where environments contain benserazide
Phenotype modified by environments containing benserazide
Human Disease Model