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ChEBI

(1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol

Term ID
CHEBI:64080
Synonyms
  • (1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydro-1H-isochromene-5,6-diol
  • A 77636
  • A-77636
  • A77636
Definition
An isochromene that is 3,4-dihydroisochromene-5,6-diol bearing additional aminomethyl and 1-adamantyl substituents at positions 1 and 3 respectively (the 1R,3S-diastereomer). Potent and selective dopamine D1-like receptor agonist (pEC50 values are 8.97 and < 5 for D1-like and D2-like receptors respectively). Displays anti-Parkinsonian activity following oral administration in vivo.
References
  • LINCS:LSM-20969
  • Patent:EP870757
  • Patent:US6057364
  • Reaxys:5855679
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_role
inverse is_conjugate_acid_of
is_conjugate_base_of
Phenotype
Phenotype resulting from (1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol
Phenotype where environments contain (1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol
Phenotype modified by environments containing (1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol
Human Disease / Model Data