Search Ontology:
ChEBI

topotecan

Term ID
CHEBI:63632
Synonyms
  • (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • 9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin
  • Topotecan
  • topotecane
  • topotecanum
(all 5)
Definition
A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.
References
(all 17)
Ontology
ChEBI  ( EBI )
Resources
CTD
Relationships
is a type of
has_role
inverse has_part
Phenotype
Phenotype resulting from topotecan
Phenotype where environments contain topotecan
Phenotype modified by environments containing topotecan
Human Disease Model
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.