tenofovir (anhydrous)

Term ID

CHEBI:63625

Synonyms

(R)-PMPA
({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid
anh. tenofovir
anhydrous tenofovir
tenofovir
tenofovir (anh.)

Definition

A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxymethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.

References

CAS:147127-20-6
DrugBank:DB00300
HMDB:HMDB0014445
KEGG:D06074
LINCS:LSM-5340
PMID:11777298
PMID:25017682
PMID:28166217
PMID:28503983
Reaxys:7415378
Wikipedia:Tenofovir

Ontology

ChEBI ( EBI )

Relationships

is a type of: nucleoside analogue phosphonic acids

nucleoside analogue phosphonic acids Show first 5 Terms
has_role: antiviral drug drug metabolite HIV-1 reverse transcriptase inhibitor

antiviral drug drug metabolite HIV-1 reverse transcriptase inhibitor Show first 5 Terms
inverse has_functional_parent: tenofovir disoproxil

tenofovir disoproxil Show first 5 Terms
inverse has_part: tenofovir hydrate

tenofovir hydrate Show first 5 Terms
inverse is_conjugate_base_of: tenofovir(1-)

tenofovir(1-) Show first 5 Terms
is_conjugate_acid_of: tenofovir(1-)

tenofovir(1-) Show first 5 Terms

Phenotype

Phenotype resulting from tenofovir (anhydrous)

Phenotype where environments contain tenofovir (anhydrous)

Phenotype modified by environments containing tenofovir (anhydrous)

Human Disease / Model Data