fludarabine phosphate

Term ID

CHEBI:63599

Synonyms

• 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine
• 2-Fluoro-ARA AMP
• 2-Fluoroadenine arabinoside 5'-monophosphate
• 2F-ara-AMP
• 9-beta-Arabinofuranosyl-2-fluoroadenine-5'-phosphate
• 9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphate)
• 9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphate
• FAMP
• Fludara
• Fludarabine 5'-monophosphate
• Fludarabine monophosphate

Definition

A purine arabinonucleoside monophosphate having 2-fluoroadenine as the nucleobase. A prodrug, it is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. Once incorporated into DNA, 2-fluoro-ara-ATP functions as a DNA chain terminator. It is used for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to, or whose disease has progressed during, treatment with at least one standard alkylating-agent containing regimenas.

References

• CAS:75607-67-9
• DrugBank:DB01073
• Drug_Central:1189
• KEGG:D01907
• PMID:10720130
• PMID:19283354
• PMID:19567212
• PMID:19862681
• PMID:19915381
• PMID:20215092
• PMID:20467451
• PMID:20514405
• PMID:20686506
• PMID:21296675
• PMID:21725721
• PMID:21736869
• PMID:21909959
• PMID:8204523
• PMID:8528057
• PMID:8651523
• Patent:WO2010046917
• Patent:WO2010133629
• Reaxys:8167686
• Wikipedia:Fludarabine

Ontology

ChEBI  ( EBI )

Resources

CTD