eribulin

Term ID

CHEBI:63587

Synonyms

(1S,3S,6S,9S,12S,14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,35R,36S)-20-[(2S)-3-amino-2-hydroxypropyl]-21-methoxy-14-methyl-8,15-bis(methylene)-2,19,30,34,37,39,40,41-octaoxanonacyclo[24.9.2.1(3,32).1(3,33).1(6,9).1(12,16).0(18,22).0(29,36).0(31,35)]hentetra
2-(3-amino-2-hydroxypropyl)hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)11,15-18,21-24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo(3,2-i)furo(2',3'-5,6)pyrano(4,3-b)(1,4)dioxacyclopentacosin-5-(4H)-one

Definition

A fully synthetic macrocyclic ketone analogue of marine sponge natural products. Inhibits growth phase of microtubules via tubulin-based antimitotic mechanism, which leads to G2/M cell-cycle block, disruption of mitotic spindles, and, ultimately, apoptotic cell death after prolonged mitotic blockage

References

CAS:253128-41-5
Drug_Central:4171
Reaxys:9893060
Wikipedia:Eribulin

Ontology

ChEBI ( EBI )

Relationships

is a type of: cyclic ketal cyclic ketone macrocycle polycyclic ether polyether ... Show All 6 Terms

cyclic ketal cyclic ketone macrocycle polycyclic ether polyether primary amino compound Show first 5 Terms
has_role: antineoplastic agent microtubule-destabilising agent

antineoplastic agent microtubule-destabilising agent Show first 5 Terms
inverse is_conjugate_acid_of: eribulin(1+)

eribulin(1+) Show first 5 Terms
is_conjugate_base_of: eribulin(1+)

eribulin(1+) Show first 5 Terms

Phenotype

Phenotype resulting from eribulin

Phenotype where environments contain eribulin

Phenotype modified by environments containing eribulin

Human Disease Model