Search Ontology:
ChEBI
enfuvirtide
- Term ID
- CHEBI:608828
- Synonyms
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- Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2
- AcTyrThrSerLeuIleHisSerLeuIleGluGluSerGlnAsnGlnGlnGluLysAsnGluGlnGluLeuLeuGluLeuAspLysTrpAlaSerLeuTrpAsnTrpPheNH2
- enfuvirtide
- N-acetyl-L-tyrosyl-L-threonyl-L-seryl-L-leucyl-L-isoleucyl-L-histidyl-L-seryl-L-leucyl-L-isoleucyl-L-alpha-glutamyl-L-alpha-glutamyl-L-seryl-L-glutaminyl-L-asparaginyl-L-glutaminyl-L-glutaminyl-L-alpha-glutamyl-L-lysyl-L-asparaginyl-L-alpha-glutamyl-L-alp
- pentafuside
- T 20
- Definition
- A synthetic 36-amino acid peptide consisting of N-acetyltyrosyl, threonyl, seryl, leucyl, isoleucyl, histidyl, seryl, leucyl, isoleucyl, alpha-glutamyl, alpha-glutamyl, seryl, glutaminyl, asparaginyl, glutaminyl, glutaminyl, alpha-glutamyl, lysyl, asparaginyl, alpha-glutamyl, alpha-glutamyl, alpha-glutamyl, leucyl, leucyl, alpha-glutamyl, leucyl, alpha-aspartyl, lysyl, tryptophyl, alanyl, seryl, leucyl, tryptophyl, asparaginyl, tryptophyl, and phenylalaninamide residues joined in sequence. An HIV fusion inhibitor, it was the first of a novel class of antiretroviral drugs used in combination therapy for the treatment of HIV-1 infection. It interferes with entry of HIV into cells by binding to the gp41 sub-unit of the viral envelope glycoprotein, so inhibiting fusion of viral and cellular membranes.
- References
-
- Beilstein:11023586
- Beilstein:11360774
- Beilstein:8758835
- Beilstein:9384544
- Beilstein:9612670
- CAS:159519-65-0
- DrugBank:DB00109
- Drug_Central:1010
- KEGG:D02499
- PMID:17485501
- PMID:25017682
- Patent:US5464933
- Patent:WO9428920
- Wikipedia:Enfuvirtide
- Ontology
- ChEBI ( EBI )
- is a type of
-
- has_role
-
Phenotype
Phenotype resulting from enfuvirtide
Phenotype where environments contain enfuvirtide
Phenotype modified by environments containing enfuvirtide
Human Disease / Model Data