Search Ontology:
ChEBI

enfuvirtide

Term ID
CHEBI:608828
Synonyms
  • Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2
  • AcTyrThrSerLeuIleHisSerLeuIleGluGluSerGlnAsnGlnGlnGluLysAsnGluGlnGluLeuLeuGluLeuAspLysTrpAlaSerLeuTrpAsnTrpPheNH2
  • enfuvirtide
  • N-acetyl-L-tyrosyl-L-threonyl-L-seryl-L-leucyl-L-isoleucyl-L-histidyl-L-seryl-L-leucyl-L-isoleucyl-L-alpha-glutamyl-L-alpha-glutamyl-L-seryl-L-glutaminyl-L-asparaginyl-L-glutaminyl-L-glutaminyl-L-alpha-glutamyl-L-lysyl-L-asparaginyl-L-alpha-glutamyl-L-alp
  • pentafuside
  • T 20
Definition
A synthetic 36-amino acid peptide consisting of N-acetyltyrosyl, threonyl, seryl, leucyl, isoleucyl, histidyl, seryl, leucyl, isoleucyl, alpha-glutamyl, alpha-glutamyl, seryl, glutaminyl, asparaginyl, glutaminyl, glutaminyl, alpha-glutamyl, lysyl, asparaginyl, alpha-glutamyl, alpha-glutamyl, alpha-glutamyl, leucyl, leucyl, alpha-glutamyl, leucyl, alpha-aspartyl, lysyl, tryptophyl, alanyl, seryl, leucyl, tryptophyl, asparaginyl, tryptophyl, and phenylalaninamide residues joined in sequence. An HIV fusion inhibitor, it was the first of a novel class of antiretroviral drugs used in combination therapy for the treatment of HIV-1 infection. It interferes with entry of HIV into cells by binding to the gp41 sub-unit of the viral envelope glycoprotein, so inhibiting fusion of viral and cellular membranes.
References
  • Beilstein:11023586
  • Beilstein:11360774
  • Beilstein:8758835
  • Beilstein:9384544
  • Beilstein:9612670
  • CAS:159519-65-0
  • DrugBank:DB00109
  • Drug_Central:1010
  • KEGG:D02499
  • PMID:17485501
  • PMID:25017682
  • Patent:US5464933
  • Patent:WO9428920
  • Wikipedia:Enfuvirtide
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from enfuvirtide
Phenotype where environments contain enfuvirtide
Phenotype modified by environments containing enfuvirtide
Human Disease / Model Data