clocortolone

Term ID

CHEBI:59582

Synonyms

9-chloro-6alpha-fluoro-11beta,21-dihydroxy-16alpha-methyl-1,4-pregnadien-3,20-dione
9-chloro-6alpha-fluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione
9-chloro-6alpha-fluoro-16alpha-methyl-1,4-pregnadiene-11beta,21-diol-3,20-dione
clocortolona
clocortolone
clocortolonum

Definition

16alpha-Methylpregna-1,4-diene-3,20-dione bearing hydroxy substituents at the 11beta and 21 positions, fluorine at position 6 and chlorine at position 9. A medium potency corticosteroid, it is used as its 21-O-pivalate or caproate ester for the relief of inflammatory and pruritic (itching) skin disorders.

References

Beilstein:6318064
CAS:4828-27-7
DrugBank:DB00838
KEGG:D07719
Patent:DE2011559
Patent:NL6412708
Patent:US3729495
Wikipedia:Clocortolone

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: 3-oxo-Delta(1),Delta(4)-steroid 11beta-hydroxy steroid 20-oxo steroid 21-hydroxy steroid chlorinated steroid ... Show All 8 Terms

3-oxo-Delta(1),Delta(4)-steroid 11beta-hydroxy steroid 20-oxo steroid 21-hydroxy steroid chlorinated steroid fluorinated steroid glucocorticoid primary alpha-hydroxy ketone Show first 5 Terms
has_role: anti-inflammatory drug antipruritic drug

anti-inflammatory drug antipruritic drug Show first 5 Terms
inverse has_functional_parent: clocortolone pivalate

clocortolone pivalate Show first 5 Terms

Phenotype

Phenotype resulting from clocortolone

Phenotype where environments contain clocortolone

Phenotype modified by environments containing clocortolone

Human Disease Model