donepezil

Term ID

CHEBI:53289

Synonyms

2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one
donepezil
donepezilo
donepezilum

Definition

A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.

References

CAS:120014-06-4
DrugBank:DB00843
Drug_Central:946
KEGG:D07869
LINCS:LSM-1598
Reaxys:7081955
Wikipedia:Donepezil

Ontology

ChEBI ( EBI )

Relationships

is a type of: racemate

racemate Show first 5 Terms
has_part: (R)-donepezil (S)-donepezil

(R)-donepezil (S)-donepezil Show first 5 Terms
has_role: EC 3.1.1.7 (acetylcholinesterase) inhibitor EC 3.1.1.8 (cholinesterase) inhibitor nootropic agent

EC 3.1.1.7 (acetylcholinesterase) inhibitor EC 3.1.1.8 (cholinesterase) inhibitor nootropic agent Show first 5 Terms
inverse is_conjugate_acid_of: donepezil (1+)

donepezil (1+) Show first 5 Terms
is_conjugate_base_of: donepezil (1+)

donepezil (1+) Show first 5 Terms

Phenotype

Phenotype resulting from donepezil

Phenotype where environments contain donepezil

Phenotype modified by environments containing donepezil

Human Disease Model