AZD7545

Term ID

CHEBI:49490

Synonyms

• (R)-4-(3-chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenylsulfonyl)-N,N-dimethylbenzamide
• 4-(3-chloro-4-{[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino}benzene-1-sulfonyl)-N,N-dimethylbenzamide
• 4-[(3-chloro-4-{[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino}phenyl)sulfonyl]-N,N-dimethylbenzamide
• AZD 7545
• AZD-7545

Definition

A sulfone that is benzene substituted by [4-(dimethylcarbamoyl)phenyl]sulfonyl, chloro and [(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino groups at positions 1, 3 and 4, respectively. It is a potent and non-ATP-competitive inhibitor of pyruvate dehydrogenase kinase 2 (PDHK2) with IC50 of 6.4 nM and exhibits glucose-lowering activity. Also inhibits PDHK1 at higher levels (IC50 = 36.8 nM).

References

• CAS:252017-04-2
• Chemspider:20572552
• DrugBank:DB07403
• LINCS:LSM-6250
• PDBeChem:AZX
• PMID:14641018
• PMID:14641019
• PMID:17602666
• PMID:17683942
• PMID:18658136
• PMID:27757958
• PMID:28199108
• PMID:28595656
• PMID:30028142
• PMID:30597326
• PMID:31495556
• PMID:33125772

Ontology

ChEBI  ( EBI )